Claw Indigenous Genomics and Ethics Laboratory

Through a blend of functional genomic, experimental, and computational methodologies, our aim is to unravel the complexities of pharmacogenomic variation and phenotypes in small populations. Employing candidate gene strategies alongside epi(genome)-wide association analysis (GWAS/EWAS) and deep mutational scanning, we pinpoint genomic regions influencing crucial aspects of drug response: absorption, distribution, metabolism, and excretion. Furthermore, we investigate patterns of genetic variation to elucidate the role of natural selection in shaping our genomes.

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Central to our mission is the incorporation of community-based participatory research (CBPR) approaches, inclusive of Indigenous cultural values and knowledge. This inclusive approach not only enhances the richness of our research but also underscores our commitment to cultural sensitivity and respect. Building on these principles, we are also at the forefront of including cultural, ethical, and social implications of genetic and genomics research with historically underrepresented communities, particularly in tribal and Indigenous communities, to guide our efforts toward meaningful and responsible science.